摘要
目的 探讨 SL E免疫功能异常的原因。方法 采用免疫荧光双标记 -流式细胞仪检测了 16例活动期 SL E患者外周血淋巴细胞的 CD43抗原。结果 1活动期 SL E患者外周血 CD43抗原阳性淋巴细胞为 6 3.14± 16 .47,低于正常人对照组 86 .6 2± 12 .86 ,有非常显著性差异 (P<0 .0 1) ;2 CD43抗原阳性淋巴细胞数与 SL E疾病活动度呈显著负相关 ,r=-0 .70 2 ,P<0 .0 1;3活动期 SL E患者外周血 CD19+ -CD43+淋巴细胞为 2 .5 5± 1.38,高于对照组 1.32± 0 .92 ,有非常显著性差异 (P<0 .0 1)。结论CD19+ -CD43+淋巴细胞的增多可能与 SL E大量产生抗 DNA自身抗体有关。
Objective To investigate the causes of im m unological disorders in SL E.Methods CD43 antigen on lym phocytes of peripheral blood in 16 cases of active SL E w as detected by im - m unoflourescent double m arker-flow cytom etry.Results The results showed that,(1) the num ber of CD43 antigen positive lym phocytes in peripheral blood of active SL E patients was 6 3.14± 16 .47,w hich w as significantly low er than that of the control group(86 .6 2± 12 .86 ,P<0 .0 1) .(2 ) The number of CD43 antigen positive cells w as negatively correlated to the disease activity of SL E (r=-0 .70 2 ,P<0 .0 1) . (3) The num ber of CD19+ -CD43+ lymphocytes in peripheral blood in active SL E was2 .5 5± 1.38w hich w as significantly higher than that of the control group (1.32± 0 .92 ,P<0 .0 1) .Conclusion The increase of CD19+ -CD43+ lym phocytes may be correlated with the production of anti-DN A autoantibody in SL E.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1998年第1期14-15,共2页
Chinese Journal of Dermatology
