摘要
目的探讨防治肾小球硬化有效而可行的方法。方法应用天然的血小板活化因子受体拮抗剂银杏叶片，预防性治疗实验性肾小球硬化大鼠。结果银杏叶片可有效地保护实验性肾小球硬化大鼠的肾小球和肾小管部分功能，显著减轻肾脏病理损伤及肾小球硬化，但对缓解肾病综合征状态无明显效果。
Objective To find out an effective and feasible therapy for progressive glomerulosclerosis. Methods Experimental glomerulosclerotic rats were treated preventively with Ginkgo biloba extract, a natural platelet activating factor (PAF) receptor antagonist. Results The glomerular and tubular functions were protected effectively, the renal lesion and glomerulosclerosis were also reduced obviously, but the proteinuria and nephrotic state weren′t improved by Ginkgo biloba extract therapy. Conclusion PAF receptor antagonist could effectively reduce renal injury and glomerulosclerosis, and PAF might be one of the important mediators of glomerulosclerosis in this model.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1998年第2期92-94,共3页
Chinese Journal of Pediatrics
基金
国家自然科学基金
关键词
肾小球硬化症
PAF
银杏叶
中医药疗法
Plant extracts Glomerulosclerosis, focal Platelet activating factor
