摘要
目的观察补充微量营养素对不同糖化血红蛋白(HbAlc)水平2型糖尿病患者感染的影响。方法将196名2型糖尿病患者随机分为两组,各组再以HbAlc6.5%为界分为两个亚组,分别补充微量营养素制剂和安慰剂,持续服用6个月。研究开始时记录饮食、运动和感染情况,研究期间每月随访一次,每隔两周记录饮食、运动和感染情况。结果结束时共有14人退出研究,失访率为7.1%,获得有效数据者182例。与对照组相比,干预组叶酸水平显著升高,不饱和铁结合力显著下降,且干预组CD4+、CD8+、CD4+/CD8+比例的变化值均显著高于对照组,干预组发热时体温和发热持续时间均显著低于对照组。干预组中HbAlc≥6.5%亚组在研究期间感冒、发热、皮肤脓肿与破溃的平均发生率均低于对照组,而HbAlc<6.5%亚组在研究期间阴道炎或泌尿道感染以及口腔溃疡的平均发生率均低于对照组。结论适量补充微量营养素可明显改善2型糖尿病患者机体内微量营养素储备情况,提高机体抗感染能力,可降低HbAlc≥6.5%的2型糖尿病患者呼吸道和皮肤感染的发生率,而对HbAlc<6.5%的2型糖尿病患者降低其泌尿生殖系统和口腔感染发生率。
Object To observe the effects of supplementation of micronutrients on the incidences of common infections in type 2 diabetic patients with different HAblc levels. Methods A randomized double blind and placebo - control trial was carried out, in which 196 type 2 diabetic patients were enrolled and randomized to tablets of micronutrients and placebo, each groups were divided into two subgroups by HbAIc level of 6.5 %, respectively for 6 months. Records of diet, exercise and infection were made every month during the study. Results Fourteen patients were excluded from the study, with the lost of follow-up rate of 7.01% ; there were 182 cases with valid data. There was no significant difference between two groups in initial study. After the study, concentration of folic acid was increased significantly, while UIBC was decreased significantly in supplementation group. Changes of CD4^＋ , CD8^＋ and CD4^ ＋/CD8^＋ in supplementation group were greater than those in placebo group. The temperature and the duration of fever in supplementation group were significantly lower than those in placebo group. In addition, the incidences of common cold, fever, dermapostasis, and skin rupture in the high HbAIC level （≥6.5%） supplementation group were lower than those in placebo group. The incidences of vaginitis, urinary tract infection, gingivitis and dental ulcer in the low HbAIc level （ 〈 6.5 % ） supplementation group were lower than those in placebo group. Conclusions Adequate supplementation of micronutrients might significantly increase micronutrient level of blood and reduce incidences of common infections in type 2 diabetic patients, specially decline incidences of respiratory tract infection and dermatic infection in type 2 diabetic patients with high HbAIc level （96.5 % ） and incidences of urogenital system infection and oral cavity infection in type 2 diabetic patients with low HbAIc level （ 〈 6..5 % ）.
出处
《实用预防医学》
CAS
2009年第2期361-364,共4页
Practical Preventive Medicine
