摘要
通过对２３个已确定ＨＬＡⅠ类型别的ＬＣＬ进行ＴＮＦ生物活性的检测，结果发现：携带ＨＬＡＢ５２型别的个体，其ＬＣＬ经ＬＰＳ刺激后，ＴＮＦ生物活性比不携带ＨＬＡＢ５２的个体低（Ｐ＜００１），且以ＨＬＡＢ５２纯合子细胞表达量最低，杂合子次之。提示，ＴＮＦ的产生可能是一种受ＨＬＡ特异性等位基因控制的遗传性状，影响ＴＮＦ的产生可能是ＨＬＡ复合体发挥免疫调节的重要因素之一。
おhe cytotoxicity of 23 HLAdefined normal LCL supernatants against TNFsensitive cell line L929 was tested.The results showed that culture supernatant of LPS stimulated LCLs from HLAB52 phenotype individuals(11 of 23) had a significant lower TNF bioactivity than those from nonHLAB52 phenotype individuals(P<001) and the HLAB52 homozygous cells(3 of 11)produce lower TNF than B52 heterozygous cells(P<0.05).These findings suggested that TNF is one of the important factor sparticipating in regulation of the immune response controlled by HLA and variation of TNF production among individuals maybe genetic trait associated with HLA polymorphism.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第4期273-275,共3页
Chinese Journal of Immunology
