摘要
目的了解我院近5年来门诊及住院患者血清嗜肺军团菌的抗体阳性率以及1～14血清型的分布特点。方法用间接免疫荧光法检测患者血清抗嗜肺军团菌血清抗体,并查询临床资料。结果1212例患者血清抗嗜肺军团菌抗体阳性163例,总阳性率为13.4%。14个血清型中,4型的抗体阳性率最高,为12.0%;其次为12型(8.5%)、5型(7.8%)、14型(6.1%)、10型(5.9%);其余血清型的抗体阳性率较低。在阳性结果中,3种血清型同时阳性最为多见,占21.0%;其次为4种或5种同时阳性。各个科室中,呼吸病科嗜肺军团菌抗体阳性检出率最高,为23.3%,其中又以4型最为多见,为19.0%,其次为12型(17.2%)。结论我院就诊患者存在不同血清型的嗜肺军团菌感染,其中以4型最为多见,不同于既往报道的西方国家1型和国内6型。嗜肺军团菌与其他病原微生物以及自身各血清型之间可能存在交叉反应,研制血清型特异的抗原用于临床检测将有助于提高抗嗜肺军团菌抗体检测的准确性。
Objective This study was designed to investigate positive rate of serum antibody and the distribution of serotypes of LegioneUa pneumophila in the patients of author＇s hospital for recent 5 years. Methods All the inspecting results of antibodies in the 1212 serums by indirect immunofluorescence from Jan 1, 2003 to Oct 31, 2007 were reviewed. The clinical information of patients was collected. Results 163 serums were positive （ 13.5% ）. Serotype 4 had the highest positive rate of 12.0% followed by serotype 12 （8.5%）, 5 （7.8%） , 14 （6.1%） , 10 （5.9%）. Three simultaneously positive serotypes were dominant （21.0%） , and 4 or 5 simultaneously positive serotypes were common. In all departments, the highest positive rate （23.3%） was in respiratory ward, in which serotype 4 and 12 were the most （ 19.0% and 17.2% , respectively）. Conclusions Serotype 4 was the most common type of LegioneUa pneumophila in serotype 1-14. Cross reaction could exist between Legionella pneumophila and other pathogenic microorganism or in different serotypes.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2009年第2期124-126,共3页
Chinese Journal of Clinical Laboratory Science
关键词
军团菌
感染
血清型
间接免疫荧光
Legionella pneumophila
infection
serotype
indirect immunofluorescence
