摘要
以全细胞膜片钳制技术观察了正常及慢性常压低氧肺动脉高压大鼠肺动脉平滑肌细胞外向钾电流，并进行了四乙铵（ＴＥＡ）对两种动脉外向钾电流作用的量效关系比较．结果表明：将细胞膜电位钳制在－５０ｍＶ，当指令电位大于－５０ｍＶ时，可以记录到电压依赖性的外向钾电流，且慢性常压低氧肺动脉高压时该电流较正常时为小；当指令电位为＋７０ｍＶ。
The outward potassium currents (Ik) of normal and chronic normobaric hypoxic pulmonary hypertensive rats and the effect of tetraethylammonium(TEA) on them were observed. The results showed that when cell membrane potential was held at -50 mV and command potential was larger than -50 mV, the Ik of pulmonary hypertensive rats was smaller than that of normal rats. When command potential was +70 mV, the doseeffect curve of TEA on the Ik of pulmonary hypertensive rats was rightshifted compared to that of normal rats.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1998年第2期98-100,共3页
Chinese Journal of Pharmacology and Toxicology
基金
中国卫生部八.五攻关资助
关键词
肺动脉高压
四乙铵
肺动脉
平滑肌细胞
pulmonary artery
hypertension
muscle
smooth
vascular
patch clamp technique
wholecell
outward potassium current
tetraethylammonium
