摘要
评价左旋氧氟沙星（LVFX）治疗细菌性感染的疗效与安全性。治疗病种包括下呼吸道、尿路、服道、创伤、烧伤感染、伤寒及淋病共205例。在下呼吸道及尿路感染中，以LVFX和阿莫西林／克拉维酸（Amoxi／Clav）作对照。结果均以LVFX组的疗效明显优于Amoxi／Clav组。用LVFX治疗145例的总有效率为93．1％，细菌清除率为91．2％。药敏试验示大多数病原菌对LVFX是敏感的，且与临床疗效相符合。LVFX300mgl次口服后的血、尿药浓度均超过大多数病原菌的最小抑菌浓度（MIC），达到有效抗菌作用。LVFX的不良反应少且轻微，说明LVFX治疗细菌性感染安全有效。
The clinical therapeutic efficacy of Levofloxacin (LVFX) for different bacterial infectiOns in 205cases was evaluated. Including 60 of lower respiratory tract infection (LRTI), 60 urinary tract infection (UTI),20billiary tract infection, 15 wound infection or burn, 30 typhoid fever and 20 acute gonorrhea. A randomized con-trolled study of LVFX vs AmoXicill in /Clavulanic acid (Amoxi/Clav ) was es pecially performed in LRTI and UTL.The results showed that the clinical effective rate of LVFX group was significantly higher than that of Amoxi/Clavgroup both in LRTI and UTL. The total clinical curative effect and bacterial clearance in 145 cases treated withLVFX were amounted to 93. 1 % and 91, 2N respectiveiy. In vitro the antibacterial activity of LVFX showed thatmost pathogenic strains were susceptib1e to the drug in correlation with clinical efficacy. The serum and urineLVFX concentrations after 300mg of the drug by oral administration exceeded the MIC of most pathogenic strainsand it would exert antibacterial action effectively. The side-effect of LVFX was mild and rarely happened. So thatLVFX mignt be effective and safe in treatment of bacterial infections.
出处
《江苏医药》
CAS
CSCD
1998年第6期396-398,共3页
Jiangsu Medical Journal
关键词
细菌性感染
药物疗法
左旋氧氟沙星
Levofloxacin Amoxicillin/Clavulanic acid Clinical study Bacterial infection
