摘要
目的评价９９ｍＴｃ（Ⅴ）二巯基丁二酸钠（ＤＭＳＡ）显像在骨转移瘤诊断中的意义。方法对１０６例疑骨转移瘤患者进行了９９ｍＴｃ（Ⅴ）ＤＭＳＡ全身显像，并与９９ｍＴｃ羟基亚甲基二膦酸（ＭＤＰ）全身骨显像及其它检查作对比。结果１０６例患者中７０例证实有骨转移，９９ｍＴｃＭＤＰ骨显像均示有异常放射性浓聚，９９ｍＴｃ（Ⅴ）ＤＭＳＡ显像６８例显示了在某些相同部位与９９ｍＴｃＭＤＰ显像有相似的放射性浓聚，２例显像呈阴性。７０例骨转移瘤患者中，９９ｍＴｃＭＤＰ显像检查出２３６个病灶，９９ｍＴｃ（Ⅴ）ＤＭＳＡ显示了其中１７５个病灶。９９ｍＴｃ（Ⅴ）ＤＭＳＡ诊断骨转移瘤的灵敏度为７４２％，特异性为１００％。２４例骨良性病变患者，９９ｍＴｃＭＤＰ骨显像示轻度异常放射性浓聚，而９９ｍＴｃ（Ⅴ）ＤＭＳＡ显像却未见异常放射性浓聚。１２例无骨转移者，９９ｍＴｃＭＤＰ与９９ｍＴｃ（Ⅴ）ＤＭＳＡ显像均未见异常。结论９９ｍＴｃ（Ⅴ）ＤＭＳＡ诊断骨转移瘤的特异性比９９ｍＴｃＭＤＰ骨显像高。
Purpose To assess the clinical value of 99m Tc(Ⅴ) DMSA imaging in diagnosis of benign and malignant lesions in bones Methods 99m Tc(Ⅴ) DMSA and 99m Tc MDP whole body bone scintigraphy was performed on 106 patients suspected of bearing bone metastases due to the complaints of bone pain For seventy patients of them, bone metastases were diagnosed; for the remainder (36 patients), only benign bone tumors, hyperosteogeny, etc were detected by means of X ray, CT and/or histopathological examinations Results All of the seventy patients with diagnosed bone metastasis had positive 99m Tc MDP scintigraphy, and 68 of them had increased 99m Tc(Ⅴ) DMSA accumulation at certain areas matched with those shown in 99m Tc MDP scintigraphy 99m Tc MDP scintigraphy demonstrated 236 bone metastatic lesions, while only 175 of the 236 bone metastatic lesions were shown by 99m Tc(Ⅴ) DMSA imaging The sensitivity, specificity of 99m Tc(Ⅴ) DMSA imaging were 74 2% and 100% respectively In addition, for twenty four patients with benign bone tumors, 99m Tc MDP scan showed slight tracer accumulation in the lesions, while 99m Tc(Ⅴ) DMSA accumulation was not seen Twelve patients had normal 99m Tc MDP and 99m Tc(Ⅴ) DMSA scans and were declared free of bone metastasis Conclusions In comparison with 99m Tc MDP scanning, 99m Tc(Ⅴ) DMSA scanning shows a higher specificity for detecting bone metastases, and possesses more significant clinical value for distinguishing benign from malignant bone tumours
出处
《中华核医学杂志》
CAS
CSCD
北大核心
1998年第2期101-103,共3页
Chinese Journal of Nuclear Medicine
基金
河北省教委科研基金
关键词
骨肿瘤
转移瘤
放射性核素显像
锝99M
DMSA
Bone neoplasms Neoplasms, secondary Radionuclide imaging Dimercaptosuccinici acid Methylene diphosphonic acid
