摘要
目的探讨银杏叶提取物（EGB）对早期糖尿病肾病（DN）患者肾的保护作用及其机制。方法将51例早期DN患者随机分为对照组（25例）和治疗组（26例），对照组为常规西药治疗，治疗组在常规治疗基础上加用EGB。用酶联免疫吸附法（ELISA）测定两组患者治疗前、后血清高敏C-反应蛋白（hs—CRP）、单核细胞趋化蛋白-1（MCP-1）表达水平，同时观察尿微量白蛋白排泄率（UAER）、空腹血糖（FPG）、SCr、BUN、血脂等指标的变化。结果治疗6个月后，对照组和治疗组血清hs—CRP从（194．37±34．02）、（191．51±27．15）mg／L分别降至（164．13±32．86）、（134．65±20．47）mg／L，MCP．1从（304．23±38．56）、（299．66±44．07）ng／L分别降至（235．43±28．66）、（165．53±21．96）ng／L。2组各指标治疗前、后比较，P均〈0．05。2组治疗后比较，治疗组hs-CRP、MCP-1下降更为明显（P均〈0．05）。结论银杏叶提取物可能通过减低血清hs—CRP、MCP-1的表达，减轻炎症反应，起到对DN患者肾的保护作用。
Objective To investigate the protective effect and possible mechanisms of extract of Gingko biloba （EGB） on early diabetic nephropathy （DN）. Methods Fifty-one patients with early DN were randomly divided into control group （n = 25 ） treated by irbesartan alone and treated group （n = 26）treated by EGB combined with irbesartan. Serum high sensitive C-reactive protein（hs-CRP） and monoeyte chemoattractant protein-1 （MCP-1） were determined with ELISA before and after treatment, and urinary albumin excretion rate （UAER） , fasting blood glucose （FBG）, serum creatinine （SCr）, blood urea nitrogen （BUN） and lipid profiles were examined as well. Results Compared with pretreatment, at the end of 6 months＇ treatment, the values of hs-CRP decreased from （ 194.37 ± 34.02 ） and （ 191.51 ± 27.15 ） mg/L to （ 164.13± 32.86 ） and （ 134.65 ± 20.47 ） mg/L in control group and treatment group, respectively. MCP-1 was downregulated from （ 304.23 ± 38.56 ） and （ 299. 66 ± 44.07 ） ng/L to （ 235.43 ± 28.66 ） and （ 165.53 ± 21.96 ） ng/L in control group and treated group （ all P 〈 0.05 ）. After treatment, the decrement of hs-CRP and MCP-1 level in the treated group was more significant than that in control group （ P 〈 0.05 ）. Conclusion EGB could retard the development of early DN, through down-regulating the expresssion of serum MCP-1, decreasing serum hs-CRP concentration and inhibiting inflammatory reaction.
出处
《中国综合临床》
2009年第3期299-301,共3页
Clinical Medicine of China
关键词
银杏叶提取物
糖尿病肾病
高敏C-反应蛋白
单核细胞趋化蛋白-1
Extract of Gingko biloba
Diabetic nephropathy
High sensitive C-reactive protein
Mon- ocyte ehemoattractant protein-1
