摘要
目的:对比米非司酮、安宫黄体酮治疗围绝经期功血的临床疗效。方法:将100例确诊为围绝经期功血的患者,随机分为米非司酮组(治疗组)与安宫黄体酮组(对照组)各50例,治疗组刮宫术后给予米非司酮10mg/d,连续服用3个月为一疗程;对照组刮宫后第15天开始服安宫黄体酮8mg/d,连服10d后停药,让子宫撤退性出血,以后每次阴道出血第15d开始服安宫黄体酮8mg/d,连服10d后停药,3个月为1疗程。结果:治疗组总有效率明显高于对照组而总复发率明显低于对照组,有显著差异。治疗前内膜厚度<10mm的总有效率明显高于内膜厚度≥10mm,而总复发率明显低于内膜厚度≥10mm,有显著差异。结论:米非司酮治疗围绝经期功血的临床疗效优于安宫黄体酮,而且治疗前子宫内膜厚度对疗效有一定程度的影响。
Objective： To compare the clinical efficacy of mifepristone tablets with that of medroxyprogesterone tablet in treatment of pert -menopausal dysfunctional uterine bleeding. Methods： 100 cases of diagnosed perimenopausal patients with dysfunctional uterine bleeding were randomly divided into mifepristone group （treatment group） and medroxyprogesterone group （control group）, each with 50 cases. Treatment group was given mifepristone tablet immediately after curettage, 10mg per day, taking 3 consecutive months for one course of treatment. Control group was given medroxyprogesterone tablet since the 15th day after curettage, 8mg per day, taking 10 consecutive days, which would lead to a withdrawal uterine bleeding. Then take medroxyprogesterone in the same way since the 15th day from each vaginal bleeding. Take 3 consecutive months for one course of treatment. Result： The total effective rate in treatment group was significantly higher than the control group, while the total recurrence rate was significantly lower. The difference was remarkable. Cases with an endometrial thickness less than lOmm before treatment had significantly higher total effective rate than those with an endometrial thickness greater than 10mm, wbile the overall recurrence rate was significantly lower. The difference was also remarkable. Conclusions ： The clinical effecacy of Mifepristone treatment to pert-menopausal dysfunctional uterine bleeding is superior to that of medroxyprogesterone, and the endometrial thickness before treatment has a certain impact on the efficacy.
出处
《赣南医学院学报》
2009年第1期60-62,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
围绝经期功能失调性子宫出血
米非司酮
安宫黄体酮
pert-menopausal period dysfunctional uterine bleeding
mifepristone
medroxyprogesterone
