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支气管哮喘患儿血浆肾上腺髓质素、肿瘤坏死因子-α水平的变化 被引量:1

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摘要 目的:观察支气管哮喘(简称哮喘)患儿血浆肾上腺髓质素(AM)、肿瘤坏死因子-α(TNF-α)水平的变化以及与气道阻力值(Rint)、外周血氧分压(PaO2)的关系。方法:采用放射免疫分析法,检测30例哮喘急性发作期患儿和30例缓解期患儿血浆的AM、TNF-α水平,并与Rint及PaO2进行相关分析。30例健康儿童为对照组。结果:哮喘急性发作期组血浆的AM、TNF-α分别为(31.45±6.51)ng/L、(1.73±0.49)ng/L,明显高于缓解组的(13.26±4.12)ng/L、(1.45±0.43)ng/L(P均<0.01)及对照组的(11.43±3.52)ng/L、(1.21±0.41)ng/L(P均<0.01)。哮喘急性发作期组血浆的AM水平与TNF-α水平及Rint呈正相关(r=0.58,P<0.01)、(r=0.73,P<0.01),与PaO2呈负相关(r=-0.55,P<0.01)。结论:AM在支气管哮喘的急性发作中起着重要的作用。
出处 《赣南医学院学报》 2009年第1期16-18,共3页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
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二级参考文献7

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