摘要
目的:研究前列瘀痛液对大鼠慢性非细菌性前列腺炎的影响及其抗炎镇痛作用。方法:采用角叉菜胶致大鼠非细菌性前列腺炎模型,观察前列瘀痛液对病理模型大鼠前列腺液中白细胞数目、卵磷脂小体密度、腺体组织形态的改变;采用二甲苯致小鼠耳肿胀的炎症模型和热板法的疼痛模型观察其抗炎镇痛作用;并观察了对小鼠耳廓微循环的影响。结果:前列瘀痛液可减少模型大鼠前列腺液中白细胞数,升高卵磷脂小体密度,减轻大鼠前列腺间质炎细胞浸润和水肿;减轻耳肿胀;提高热板法小鼠痛阈值;还可改善小鼠耳廓微循环。结论:前列瘀痛液具有改善大鼠非细菌性前列腺炎的作用。
OBJECTIVE To investigate the effects of Qianlie Yutong liquid on chronic nonbacterial prostatitis and its anti-inflammatory and analgesia activity. METHODS Chronic nonbacterial prostatitis model was induced by injecting carrageengel solution into the prostate of rat , and then the changes of WBC number, lecithin corpuscular density and prostatic histomorphology were observed. Anti inflammatory effects were studied by dimethylbenzene-induced ear tumefaction, analgesia activity was tested by hot-plate model and auricle circulation was observed in mice. RESULTS Qianlie Yutong liquid markedly reduced WBC, increased lecithin corpuscular density , decreased inflammatory cell infiltration of prostatic tissue in rats, lessened ear tumefaction , elevated the latency in hot plate model and improved auricle tiny circulation in mice. CONCLUSION Qianlie Yutong liquid has the effect on experimental chronic nonbacterial prostatitis.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第6期459-462,共4页
Chinese Journal of Hospital Pharmacy
基金
陕西省社发攻关项目(编号:2006k15-G5)
关键词
前列瘀痛液
慢性非细菌性前列腺炎
抗炎
镇痛
Qianlie Yutong liquid
chronic nonbacterial prostatitis
anti-inflammation
analgesia
