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抑癌基因RASSF1A在胰腺癌组织中表达的研究 被引量：2

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摘要 目的探讨抑癌基因RASSF1A在胰腺癌组织中的表达及其与胰腺癌发生、发展的关系。方法采用免疫印迹方法检测4 8例胰腺癌组织及其癌旁(正常)组织RASSF1A基因蛋白的表达水平。结果癌旁组织RASSF1A蛋白的表达量高于高分化腺癌组织的表达量(P<0.0 5);高分化腺癌组织RASSF1A蛋白的表达量高于中、低分化腺癌组织(P<0.0 5)。TNM分期Ⅲ期RASSF1A蛋白的表达量低于Ⅰ,Ⅱ期(P<0.0 5)。RASSF1A基因蛋白表达与性别、年龄,肿瘤发生部位无明显关系(P>0.05)。结论RASSF1A表达缺失或低下在胰腺癌的发生、发展中起重要作用。
作者 武林枫 王逢春 马玉刚 翟博 赵福龙 孟庆辉
机构地区 哈尔滨医科大学第一医院肝胆胰腺外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2009年第3期292-294,共3页 China Journal of General Surgery
基金 哈尔滨市科技创新人才研究专向资金项目(2006RFQXS079)
关键词 胰腺肿瘤/病理学 RASSF1A 基因 基因表达
分类号 R735.9 [医药卫生—肿瘤]
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参考文献11

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二级参考文献45

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中国普通外科杂志
2009年 第3期

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