摘要
对不同类型格林-巴利综合征病人血清中所含抗格林-巴利综合征病人分离株空肠弯曲菌、动物来源株空肠弯曲菌、北京对照用人源性空肠弯曲菌及其脂多糖抗体进行分析,结果显示,AMAN病人血清中含有高滴度抗AMAN病人感染株空肠弯曲菌LPS的抗体,同时含有较弱的抗当地分离株空肠弯曲菌LPS的抗体,但不含有抗对照组空肠弯曲菌LPS的抗体,AIDP病人血清中不含有抗空肠弯曲菌LPS的抗体,仅含有较弱的抗空肠弯曲菌蛋白抗原的抗体,表明抗空肠弯曲菌LPS抗体的产生与AMAN的发生密切相关;若某些AIDP的发生与空肠弯曲菌感染相关,则其发生也与抗空肠弯曲菌LPS抗体的产生无明显关系。AIDP与AMAN病人在发病机理上存在明显不同,对临床GBS病人血清中抗空肠弯曲菌LPS抗体的检测,可能对AMAN与AIDP的鉴别诊断具有重要意义。
The anti-C. jejuni LPS antibodies differences between the Guillain-Barre syndrome (GBS) subtypes, acute motor axonal neuropathy (AMAN) and AIDP, were studied by SDS-PAGE and Western blot analysis. The result showed that the AMAN patients have obvious anti-LPS of C. jejuni, which was isolated from AMAN patient's stool, but AIDP patients have no C. jejuni LPS antibodies. To identify and distinguish between AMAN and AIDP, it may be important to detect anit-C. jejuni LPS antibodies in GBS patients.
出处
《脑与神经疾病杂志》
1998年第1期15-17,共3页
Journal of Brain and Nervous Diseases
