摘要
目的探讨小剂量三尖杉酯碱（HT，H）和阿糖胞苷（Ara-c,A）联合粒细胞集落刺激因子（G-CSF）治疗老年人急性髓细胞白血病的疗效及不良反应。方法35例AML患者均给予HT1mg·m^-2·d^-1，静脉滴注，第1—14天；Ara—c 10mg·m^-2，静脉滴注，每12h注射1次，第1～14天；G-CSF100—200μg·m^-2·d^-1，皮下注射，在第1次注射Ara—c之前开始使用，至最后1次注射Ara-c之前停用。结果35例AML患者化疗后完全缓解16例（46％）、部分缓解14例（37％），总有效率83％，未缓解（NR）5例（14％）；2例患者化疗期间死亡。主要不良反应为骨髓抑制。结论小剂量HA方案联合G—CSF治疗老年人急性髓细胞白血病安全、有效。
Objective To evaluate the efficacy and toxicity for the protocol of low-dose harringtonine and cytarabine（ HA regimen） in combination with granulocyte colony-stimulating factor（G-CSF） in elderly patients with acute myelogenous leukemia（AML）. Methods Thirty-five AML patients were treated with HAG including low-dose harringtonine（ 1mg ·m^-2·d^-1 per day,day1 to 14） ,cytarabine（ 10mg · m^-2 ,per 12 hours,day 1 to 14） and G-CSF （100-200μg·m^-2 ·d^-1 perday,day 1 to14）.Results 16of35（46%） patients achievedCR,14of35（37%） achieved PR. The overall response rate was 83%. 5 of 35 （14%） was non-remission. Two patients died in the duration of treatment. The main complication of chemotherapy is myelosuppresion. Conclusion Low-dose HA regimen in combination with G-CSF is effective and safe in elderly patients with AML.
出处
《中国基层医药》
CAS
2009年第2期247-248,共2页
Chinese Journal of Primary Medicine and Pharmacy
