摘要
目的：探讨脑血栓血瘀证与血管内皮细胞纤溶功能及血小板活化程度的关系。方法：检测３０例脑血栓血瘀证患者急性期血浆组织型纤溶酶原激活剂（ｔＰＡ）、纤溶酶原激活剂抑制物（ＰＡＩ）和α颗粒膜蛋白（ＧＭＰ１４０）的含量。结果：脑血栓血瘀证患者与健康对照组的纤溶功能和血小板活化指标有明显差异。患者血浆ｔＰＡ〔（１．３１±０．４７）ｋＵ／Ｌ〕明显低于对照组〔（１．８９±０．５０）ｋＵ／Ｌ〕，而ＰＡＩ和ＧＭＰ１４０〔分别为（８．７５±２．３２）×１０３ＡＵ／Ｌ和（２７．８５±８．６０）μｇ／Ｌ〕则明显高于对照组〔分别为（６．６１±１．６７）×１０３ＡＵ／Ｌ和（１３．３１±３．４２）μｇ／Ｌ〕。结论：脑血栓血瘀证的发病与纤溶功能减退及血小板活化程度的变化密切相关。
Objective:To explore the relationship of blood stasis syndrome of cerebral embolism to fibrinolytic function of vascular endotheliocyte and platelet activating level.Methods:The plasma tissue plasminogen activator(tPA),plasminogen activating inhibitor(PAI) and granule membrane protein140(GMP140) contents were detected in 30 cases of blood stasis syndrome of cerebral embolism.Results:It was obvious difference of fibrinolytic function and platelet activation between cerebral embolism patients and health subjects.Plasma tPA〔(131±047)kU/L〕 level in patients was lower obviously than that in control group〔(189±050)kU/L〕,but PAI〔(875±232)×103 AU/L〕 and GMP140 level〔(2785±860)μg/L〕 were higher obviously than control group〔(661±167)×103AU/L and (1331±342)μg/L,respectively〕.Conclusions:The pathogenesis of blood stasis syndrome of cerebral embolism was related closely to decrease of fibrinolytic function and change in platelet activation.
关键词
脑血栓
纤溶酶原激活剂
抑制物
Α-颗粒膜蛋白
cerebral embolism\ \ tissue plasminogen activator\ \ plasminogen activating inhibitor\ \ granule membrane protein140
