摘要
目的了解广东地区儿童麻疹免疫水平,客观评价人群麻疹免疫状况,为调整策略并改进工作提供依据。方法采取分层整群抽样法抽取南海、盐田、饶平、乳源、德庆、遂溪6个县4个年龄组1 376名儿童,对其麻疹抗体水平进行检测。结果6个地区麻疹IgG抗体总阳性率为96.9%,麻疹IgG抗体总保护率为80.2%,总抗体几何平均浓度(GMC)为1 515mIU/ml;不同地区儿童麻疹抗体阳性率、保护率和抗体几何平均浓度(GMC)均有显著性差异;年龄别儿童麻疹抗体阳性率差异无显著性,但麻疹保护率和抗体几何平均浓度(GMC)存在显著性差异;外地与本地儿童麻疹抗体阳性率、保护率和抗体几何平均浓度(GMC)均显示无显著性差异。结论结果显示调查地区抗体总阳性率维持高水平,但珠江三角洲经济发达地区常规免疫工作质量要好于非珠江三角洲经济欠发达地区;麻疹复种工作可有效减少免疫空白儿童,维持人群麻疹高免疫水平;居住时间较长的流动儿童可以获得高的麻疹免疫水平,结合麻疹发病情况,需重点关注居住时间较短的流动儿童免疫状况。
Objective To understand the level of measles immunity in school-age children in some regions of Guangdong Province in 2007. Method There 1 376 children were randomly selected from The counties of Nanhai, Yantian, Raoping, Ruanyuan, Deqing, Suixi, aged 1-8 years. ELISA quantitative method to test the level of measles IgG antibody. Results The positive rate of measles antibody was 96.9% and protective rate against measles was 80.2%. The geometric mean concentration （GMC）was 1 515mIU/ml. The differences of positive rate, protective rate and GMC among counties and protective rate and GMC among age group were statistically significant （P〈0.01）. While there is no significant difference in positive rate among age group, protective rate and GMC between local and floating children. Conclusions Though the total measles antibody level is high in these counties, it indicated that the effect of routine immunity work at Pearl Delta of Guangdong is better than other areas. Revaceination of measles is the efficient way to reduce the quantities of non-vaccinated children and maintain higher level of IgG antibody. The vaccination status of children in floating population be monitored.
出处
《中国热带医学》
CAS
2009年第4期725-726,共2页
China Tropical Medicine
