摘要
目的:观察静脉注射氢化可的松对芬太尼诱发咳嗽反射(FIC)的抑制效果。方法:160例择期行腹部手术患者随机分为2组,组Ⅰ静脉滴注生理盐水100mL;组Ⅱ氢化可的松100mg加入至100mL生理盐水中静脉滴注。2组均在15min后经静脉注射芬太尼2μg.kg-1,注射时间2s。观察2组咳嗽发生的次数和出现时间及药品不良反应。结果:2组FIC发生率分别为35%(组Ⅰ)和10%(组Ⅱ),组Ⅱ明显低于组Ⅰ,2组间差异有统计学意义(P<0.05)。咳嗽程度、咳嗽出现时间2组间差异无统计学意义。2组生命体征平稳,均未出现恶心、呕吐、呼吸抑制等不良反应。结论:麻醉诱导时提前15min静脉注射100mg氢化可的松可能是一种较为理想的降低FIC发生率的方法。
OBJECTIVE： To evaluate the inhibitory effect of hydrocortisone on fentanyl- induced cough reflex （FIC） . METHODS： 160 patients undergoing scheduled operation on abdominal region were randomized to receive Normal Saline 100 mL （Group Ⅰ ） or hydrocortisone 100 mg added to 100 mL Normal Saline iv gtt （Group Ⅱ） ; 15 minutes later, both groups were injected intravenously with fentanyl （2μg · kg ^-1） with injection time of 2 seconds. The frequency and the onset time of cough as well as the adverse drug reactions in the two groups were observed. RESULTS： The FIC incidence in Group Ⅱ was significantly lower than in Group Ⅰ （10% vs. 35%）, showing significant differences between the two groups （P〈0.05） . However, no significant differences were noted between the two groups in the severity and the onset time of cough. The vital signs in both groups were stable and no adverse effects such as nausea, vomiting or respiratory depression occurred. CONCLUSION： Pretreatment with intravenous injection of 100mg hydrocortisone might be an ideal method conducive to the reduction of FIC incidence.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第8期612-613,共2页
China Pharmacy
