摘要
目的：测定环抱霉素A在5例人胚腺垂体移植患者体内的药-时曲线，据此测算其体内代谢动力学参数。方法：采用荧光偏振免疫法，测定环孢霉素A血药浓度，用MCPKP序计算药动学参数。结果：CSA在人胚腺垂体移植患者体内的过程呈二室模型，其动力学参数是t1/2Ka=0．6±0．16h，t1/2α=0．96±0．32h，t1/2β=8．69±263h，Tmax=1.73±0.31h。结论：该研究为休儒症患者合理使用CSA，制定给药方案提供一定科学依据。
AIM:To determine the drug-time curve of cyclosporine A (CsA)in 5 patients receiving transplantation of human embryo adenohypophysial cells.Based on the results,to calculate the in vivo pharmacokinetic parameters. METHoDS: The plasma concentrations of CsA were detected by fluorescence polarization immunoassay and the MIPKP program was used to calculate the pharmacokinetic parameters. RESULTS: The in vivo metabolic process of CsA in these pati ents could be best described by two compartment model: The pharmacokinetic parameters were as follows:t1/2ka=0.6±0.16h,t1/2α= 0.96±0.32h,t1/2β=8.69±2.63h,Tmax= 1.73±0.31h.CONCLUSION:The study will provide a scientific basis for rational use of CsA and scheme formulation of drug dose administed in dwarf patients.
出处
《中国药房》
CAS
CSCD
1998年第2期79-79,共1页
China Pharmacy
关键词
环孢素A
荧光偏振免疫法
药代动力学
cyclosporine A, fluorescence polarization immunoassay, pharmacokinetics
