摘要
以盐酸为催化剂合成了胆酸酯(2a～2d);用甲基丙烯酸酐(MAA)做酰化剂,4-二甲氨基吡啶(DMAP)做催化剂,三乙胺(Et3N)做缚酸剂,对2a～2d分子中伯羟基选择酰化,合成了分子中含有一个乙烯基的胆酸衍生物(3a～3d);应用溶液聚合方法制备了3a～3d均聚物及3a～3d与N-异丙基丙烯酰胺(NIPAA)的共聚物,并研究了聚合物的性能。结果显示:pH值为3～4时,反应得到2a～2d的产率最高;MAA做酰化剂,2a～2d分子中的伯羟基优先发生酰化反应;以胆酸为侧基的线性高分子化合物的性质随着二醇碳原子数增加而呈规律性变化。
Polymers can be made from natural compounds like bile acids as an effort to be more biocompatible. Cholic acid, one of the common bile acids, has been coupled with diols containing 2, 4, 6 or 8 carbons through esterification. These cholates were further transformed into macromonomers by reacting with methacryloyl anhydride （MAA） as the acrylating agents. Multi-functional homopolymers and copolymers with thermosensitive Nisopropylacrylamide have been prepared and characterized. The results shew that the length of the aliphatic chains of the diols had a significant effect on the properties of resulted polymers.
出处
《高分子通报》
CAS
CSCD
北大核心
2009年第3期36-41,共6页
Polymer Bulletin
基金
天津市科技型中小企业创新基金资助项目(项目编号:08ZXCXSH05300)
