摘要
目的：主要检测铜药复合型ＩＵＤｓ中ＬＮＧ在体内外长期释放的稳定性。方法：在体外释放介质中连续测定药物释放一年，测得平均日释放量为６．２３±０．２２μｇ。在稳态释放阶段药物释放速率是一个常数。铜材溶蚀对药物释放没有影响。２１名带器３０天至５４０天的志愿受试者，经节育器ＬＮＧ残留量分析。结果：在稳态释放阶段平均日释放量为６．９８±１．９４μｇ／ｄａｙ，与体外ＬＮＧ释放特征基本相同。结论：释放率检验证明节育器中ＬＮＧ在体内外的释放率是稳定的，符合设计要求。
Objective:The purpose to determine stability of LNG releasing of LNG-Cu-IUD in vivo and in vitro Methods:The average releasing rate of LNG at medium for a year was 623±022ug/day During steady releasing state,releasing rate of LNG was a constant Corrosion of copper from devices did not interfere drug releasing 21 of volunteers were involved in this study for 540 days By the method of remnant LNG analysis, the average steady state releasing rate per day was 698ug/day±194ugResults: The characteristics of drug releasing were similar in vivo and in vitro Conclusions:It is concluded that the releasing rate of LNG in vivo and in vitro is stable and accords with demands of experimental design
出处
《天津医科大学学报》
1998年第1期19-20,共2页
Journal of Tianjin Medical University
基金
八五攻关课题
