摘要
为探索芳香植物的香气成分对神经系统的调节作用。采用两种抑郁模型小鼠尾悬挂试验和小鼠强迫游泳试验,对迷迭香(Rosmarinus officinalis L.)和柠檬草(Cymbopogon citrates)的精油以及活体香气的抗抑郁作用进行了研究。结果显示,与生理盐水对照组相比较,迷迭香和柠檬草的精油各剂量以及活体香气各浓度都可以使小鼠尾悬挂的失望时间和小鼠强迫游泳的不动时间显著缩短,但普遍比氟西汀的作用弱。在小鼠尾悬挂试验中,效果最好的四种依次为:氟西汀、迷迭香精油中剂量、迷迭香植物低浓度、柠檬草精油大剂量,与生理盐水对照组相比,不动时间分别缩短了56.6%、52.7%、35.9%、34.1%;在小鼠强迫游泳试验中,效果最好的四种依次为:迷迭香精油中剂量、氟西汀、迷迭香植物低浓度、柠檬草精油大剂量,与生理盐水对照组相比,不动时间分别缩短了40.1%、36.3%、35.3%、35.1%。由此可见,迷迭香和柠檬草的精油以及活体香气,具有一定的抗抑郁作用。
In order to promote the using value of the aromatic plant, further explore its function on the nervous system. By using the mouse forced swimming test（FST）and mouse tail suspension test（TST）models of depression to assess the antidepressant effect of the essential oil（EO）and the volatile organic compounds in air（VOCs）from rosemary and lemongrass. All groups of the EO and the VOCs significantly shortened the motionless time and despair time in the two behavioral despair animal models of depression, and the results are significantly different to the control group. But the pharmacology function of the EO and the VOCs are generally weaker than the fluoxetine. The result of TST showed that the best four groups are successively： the fluoxetine, the EO of rosemary at medium dosage, the VOCs of rosemary in low density and the EO of lemongrass at high dosage. And the motionless time are seperately shortened by 56.6%, 52.7%, 35.9% and 34.1%. The result of FST showed that the best four groups are successively： the EO of rosemary at medium dosage, the fluoxetine, the VOCs of rosemary in low density and theEO of lemongrass at high dosage. And the motionless time are seperately shortened by 40.1% ,36.3%,35.3% and 35.1%. We can draw the conclusion that the EO and the VOCs from rosemary and lemongrass presented obviously antidepressant effect in the behavioural despair models of depression.
出处
《上海交通大学学报（农业科学版）》
2009年第1期82-85,共4页
Journal of Shanghai Jiaotong University(Agricultural Science)
关键词
迷迭香
柠檬草
精油
活体香气
抗抑郁
rosemary
lemongrass
essential oil
volatile organic compounds in air
antidepressant effect
