摘要
目的通过诊断试验Meta分析,综合评价间接血凝集试验(IHA)和酶联免疫吸附试验(ELISA)对日本血吸虫病的诊断效果。方法通过检索Pubmed、SCI、CNKI、Proquest、维普等数据库,获得公开发表的关于日本血吸虫血清学诊断试验的文献,提取相关数据。采用SAS8.02进行统计分析,利用Excel2003绘制SROC曲线图。结果15篇文献符合纳入标准,Meta分析稳健法结果显示IHA法的综合灵敏度为0.721,诊断优势比为6.686。ELISA法的综合灵敏度为0.633,诊断优势比为2.963。结论两种血清学诊断试验(IHA和ELISA)对日本血吸虫病的诊断准确度中等,IHA略高于ELISA,但差异无统计学意义。两种诊断方法对日本血吸虫病均具备一定的诊断价值。
Objective To investigate the concerned tests efficacy of enzyme-linked immunosorbent assay （ELISA） and indirect hemagglufination assay （IHA） in the diagnosis of schistosomiasis japonica. Methods Original articles were searched in the Pubmed, Science Citation Index Expanded （ SCI ）, CNKI, Proquest and VIP Information. Analysis was undertaken using SAS Software, version 8.02 and SROC （ summary receiver operating characteristic） curve was given by Excel 2003. Results Fifteen articles were included in our research. The results of meta-analysis revealed that the accuracy of IHA （ TPR = 0. 721 ） with DOR （ 6. 686 ） is higher than that of enzyme-linked immunosorbent assay （ TPR = 0. 633, DOR = 2. 963 ）. Conclusion Both IHA and ELISA can be used in diagnosis of schistosomiasis japonicum for the accuracy of them are moderate. The result of Z test can not prove that a significant difference exist between the two methods in screening of schistosomiasis.
出处
《中国卫生统计》
CSCD
北大核心
2009年第1期45-48,共4页
Chinese Journal of Health Statistics
基金
国家自然科学基金资助(30371254)
