摘要
目的分析高尿酸血症和痛风患者外周血中白介素-10(interleukin-10,IL-10)水平,探讨其变化特点。方法收集同济大学附属东方医院2007年门诊及住院患者并分组,其中高尿酸血症组42例,痛风组46例,正常组40例,采用酶联免疫法检测高尿酸血症、痛风患者及正常人外周血上清中IL-10水平以及痛风及高尿酸血症患者的尿酸水平,并作统计学分析。结果IL-10水平在痛风和高尿酸患者外周血中均明显高于正常对照组(P<0.01),且IL-10水平在痛风患者外周血中明显高于高尿酸血症患者(P<0.01)。相关性分析提示IL-10水平与尿酸水平呈正相关(P<0.05)。结论痛风与高尿酸血症患者外周血中抑炎因子IL-10水平的升高并不能有效抑制痛风性关节炎症的发生。
Objective To study the levels of IL-10 in peripheral blood of hyperuricacidemia and the gout patients. Methods Forty patients with hyperuricacidemia, 46 patients with gout and 40 normal control patients in East Hospital in 2007 were collected. The peripheral blood IL-10 levels in the three groups were measured by ELISA. At the same time, the uric acid in patients with hyperuricacidemia and gout were collected. Results The levels of IL-10 in hyperuricacidemia and gout patients were much higher than those in normal control patients （P 〈 0.01 ）, and the levels of IL-10 in gout patients were also much higher than in hyperuricacidemia patients （ P 〈 0.01 ）. The correlation analysis showed that IL-10 had positive correlation with uric acid （ P 〈 0.05 ）. Conclusion The elevated IL-10 level in hyperuricacidemia and gout patients cannot effectively inhibit the gout inflammation.
出处
《同济大学学报（医学版）》
CAS
2009年第1期101-103,共3页
Journal of Tongji University(Medical Science)
