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铼羰基化合物标记含RGD的多肽 被引量：3

Radiolabeling RGD-Peptide Using fac-[^(188)Re(CO)_3(H_2O)_3]^+
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摘要 αvβ3是一种在包括肿瘤引起的血管增生及肿瘤转移中起重要作用的细胞黏附受体,含RGD序列的肽及其类似物可以作为拮抗剂与αvβ3正常配体进行竞争结合。本工作以三羰基铼为前体标记了2个含有RGD序列的多肽,实验结果表明,2个多肽的标记率和放化纯度均大于90%,体外稳定性良好。将进一步对其进行生物评价,以判别其是否有潜力发展成为肿瘤治疗剂。 Integrin αvβ2 is a member of the integrin family, which plays an important role in angiogenesis and tumour metastasis. The peptides containing arginine-glycine-aspartic acid（RGD） sequence can bind to integrin αvβ3 selectively. In the present study, we labeled two RGD-peptides via fac-[^188Re（CO）3 （H2O）3]＋. The results show that the labeling yields are more than 90% for both of radiolabeled compounds, and they are all stable in phosphate buffered saline and new-born calf serum, even challenged in histidine or cysteine solution. We will evaluate their biological properties to develop radiolabeled agents for tumor therapy.
作者 马玉飞 于俊峰 周伟 沈华 胡伟青 尹端沚
机构地区 中国科学院上海应用物理研究所
出处 《核化学与放射化学》 CAS CSCD 北大核心 2009年第1期23-27,共5页 Journal of Nuclear and Radiochemistry
基金 国家自然科学基金资助项目(20501022 32100601) 中国科学院知识创新工程重大项目(KJCXI-SW-08)
关键词 188Re ΑVΒ3 RGD 188Re,αvβ3 RGD
分类号 R817 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献20

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二级参考文献33

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共引文献13

同被引文献65

  • 1方光光,王迪,唐良振,石文芳.RGD-rAAV2提高卵巢癌细胞体外基因转导效率的研究[J].华中科技大学学报（医学版）,2006,35(2):209-212. 被引量：1
  • 2唐林,于俊峰,郑明强,夏姣云,尹端沚.铼[^(188)Re]羰基化合物标记含RGD的环肽及其生物分布[J].核技术,2006,29(6):448-452. 被引量：3
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引证文献3

二级引证文献6

核化学与放射化学
2009年 第1期

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