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WT1蛋白在上皮性卵巢癌组织中的表达意义研究 被引量：3

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摘要 目的:检测上皮性卵巢癌组织中WT1蛋白的表达,探讨其临床病理学意义及在上皮性卵巢癌发生、发展中的作用。方法:采用免疫组化SP法检测正常卵巢组织20例及卵巢良性上皮性肿瘤20例及上皮性卵巢癌20例,上皮性卵巢癌40例标本中WT1蛋白的表达情况。结果:上皮性卵巢癌组织中WT1阳性表达率为57.5%,显著高于正常卵巢组织及卵巢良性上皮性肿瘤(P<0.01);卵巢交界性上皮性肿瘤组织中WT1阳性表达率为45.0%,也显著高于正常卵巢组织及卵巢良性上皮性肿瘤(P<0.01);在上皮性卵巢癌中,浆液性囊腺癌WT1蛋白的阳性表达率(90.9%),显著高于其他亚型(P<0.01)。结论:WT1可能成为卵巢上皮性肿瘤恶性转化和上皮性卵巢癌鉴别诊断的客观辅助指标,并为其诊断及预后判断提供重要参考。
作者 霍晓溪 刘晓军 杨力 刘彦
机构地区 第二军医大学附属长征医院
出处 《人民军医》 2009年第3期167-168,共2页 People's Military Surgeon
关键词 上皮性卵巢癌 WT1 免疫组织化学 病理学
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献6

  • 1Call KM, Glaster T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms'tumor locus[J]. Cell, 1990,60 : 509-520.
  • 2Pritehard JK, Fleming S, Davidson D, et al. The candidate Wilms turnout gene is involved in genitourinary development[J]. Nature, 1990,346 : 194-197.
  • 3Hylander B, Repasky E, Shrikant P, et al. Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer[J]. Gynecol Oncol, 2006,101(1) :12-17.
  • 4Siberstein GB, VanHorn K, Strickland P,et al. Altered expression of Wilms tumor suppressor gene in human breast cancer[J].Proc Natl Acad Sci USA,1997,94(15):8 132-8 137.
  • 5Goldstein NS, Bassi D, Uzieblo A. WT1 is an integral component of the antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms[J]. Am J Clin Pathol ,2001,116(2) :246-252.
  • 6郭立丽,刘少扬,江大琼.WT1在上皮性卵巢癌中的表达及意义[J].现代肿瘤医学,2007,15(3):398-401. 被引量：2

二级参考文献13

  • 1Sugiyama H.Wilms' tumor gene WT1:its oncogenic function and clinical application[J].Int J Hematol,2001,73(2):177～187.
  • 2Roberts SG.The modulation of WT1 transcription function by cofactots[J].Bioehem Soc Symp,2006,(73):191～201.
  • 3Sotobori T,Ueda T,Oji Y,et al.Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcoma[J].Cancer,2006,106(10):2233～2240.
  • 4Gillmore R,Xue SA,Holier A,et al.Detection of Wilms' tumor antigen-specific CTL in tumor-draining lymph nodes of patients with early breast cancer[J].Clin Cancer Res,2006,12(1):34～42.
  • 5Oji Y,Suzuki T,Nakano Y,et al.Overexpression of the Wilms' tumor gene WT1 in primary astmcytic tumors[J].Cancer Sci,2004,95(10):822～827.
  • 6Sarfstein R,Maor S,Reizner N,et al.Transcriptional regulation of the insulin-like growth factor-1 receptor gene in breast cancer[J].Mol Cell Endocrinol,2006,252(1～2):241～246.
  • 7Munoz-Chapuli R,Macias D,Gonzalez-Iriarte M,et al.The epicardium and epieardial-derived cells:multiple functions in cardiac development[J].Rev Esp Cardiol,2002,55(10):1070～1082.
  • 8Alami J,Williams BR,Yeger H.Derivation and characterization of a Wilms' tumour cell line,WiT 49[J].Int J Cancer,2003,107(3):365～374.
  • 9Simpson LA,Burwell EA,Thompson KA,et al.The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy[J].Blood,2006,107(12):4695～4702.
  • 10Jomgeow T,Oji Y,Tsuji N,et al.Wilms' tumor gene WT1 17AA (-)/KTS (-) isoform induces morphological changes and promotes cell migration and invasion in vitro[J].Cancer Sci,2006,97(4):259～270.

共引文献1

同被引文献30

  • 1王淑华,辛晓燕,陈亚琼,王德堂,郭会玲.卵巢上皮性肿瘤中NF-кB与Survivin的表达及相关性[J].第四军医大学学报,2005,26(11):1029-1032. 被引量：7
  • 2赵谢兰,雷瑚仪,高欣,陈方平.NF-κB活性变化对HL-60细胞凋亡及WT1、Bcl-2基因表达的影响[J].中国现代医学杂志,2006,16(6):866-868. 被引量：4
  • 3Call KM, Glaster T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptidc gene at the human chromosome 11 Wilms' tumor locus[J]. CELL, 1990, 60:509 -520.
  • 4Miwa H, Beran M, Saunders GF, et al. Expression of the tumor gene ( WT1 ) in human leukemia[ J ]. Leukmia, 1992,6:405 - 408.
  • 5Sugiyama H. Wilms' tumor gene WT1: its oncogenic function and clinical application [ J]. Int J Hematol, 2001,73 (2) : 177 - 187.
  • 6Kristian P, Arne O, Mats S, et al. Inhibtion of platelet-deried Growth Factor Receptor reduces interstitial hypertension and increase transcapillary transport in tumor[ J]. Cancer Res,2001,61:2929 - 2934.
  • 7Skimisdotir I, Sorbe B, Scidal T. The growth factor receptors HER - 2/neu and EGFR, their relationship, and their effects on the progno- sis in early stage (FIGO Ⅰ -Ⅱ) epithelial ovarian carcinoma[ J ]. Int J Gynecol Cancer, 2001,11 (2) : 119 - 129.
  • 8Hylander B, Repasky E, Shrikant P, et al. Expression of Wilms tumor gene ( WT1 ) in epithelial ovarian cancer [ J]. Gynecol Oncol, 2006 Apr,101 (1) :12 -17.
  • 9McGuire WP,Rowinsky EK,Rosenshein NB,et al.Taxol:a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms[J].Ann Intern Med,1989,111(4):273-279.
  • 10Sui M,Chen F,Chen Z,et al.Glucocorticoids interfere with therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors[J].Int J Cancer,2006,119(3):712-717.

引证文献3

二级引证文献2

人民军医
2009年 第3期

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