摘要
目的观察腹腔镜和开腹结直肠癌根治术患者术后全身炎症反应综合征（SIRS）的发生，比较两种不同手术方式对患者的创伤程度。方法将85例结直肠癌患者分成开腹手术组（OP组，n=33）和腹腔镜手术组（LP组，n=52），检测术后患者SIRS发生率和持续时间，采用酶联免疫吸附法（ELISA）连续检测血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6及IL-10水平。结果与OP组比较，LP组患者血清TNF—α和IL-6水平明显降低，IL-10水平升高，差异有统计学意义（P〈0．01）。LP组SIRS发生率为36．5％，低于OP组的63．6％（P〈0．01），SIRS持续时间短于OP组（P〈0．05）。结论腹腔镜结直肠癌根治术术后患者SIRS发生率和程度较低，对机体创伤较小。
Objective To compare the surgical invasiveness of laparoscopic radical resection on colorectal cancer with that of open surgery when the invasiveness is evaluated by the incidence of systemic inflammatory response syndrome （SIRS）. Methods Patients with colorectal cancer who underwent open radical resection （ OP group, 33 patients） and those who underwent laparoscopic radical resection （ LP group,52 patients） were included in this study. We prospectly investigated the incidence and duration of SIRS in the two groups. Enzyme-linked immunoadsorbent assay （ELISA） was used to determine the serum levels of tumor necrosis factor alpha （ TNF-α）, interleukin-6 （IL-6） and interleukin-10 （IL-10） at the beginning of surgery and on 1,3,5,7 day after surgery. Results No patient had any severe or life-threatening complications. Levels of TNF-α and IL-6 in patients received laparoscopic radical resection were significantly lower than those in control group （P 〈 0.01 ）, meanwhile, IL-10 concentration in LP group significantly higher than OP group. The incidence of SIRS in LP group was 36.5% , which was lower significantly than OP group （63.6% ,P 〈0.01 ）. The mean duration of SIRS was 4.8 days in the open group and 2.7 days in the laparoscopic group （ P 〈 0.05 ）. Conclusion Laparoscopic radical resection seems less invasive than open surgery,when the magnitude of the invasiveness is evaluated by the incidence of SIRS.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第3期383-385,共3页
Chinese Journal of Experimental Surgery
关键词
结直肠肿瘤
腹腔镜术
全身炎症反应综合征
炎症因子
Colorectal neoplasms
Laparoscopy
Systemic inflammatory response syndrome
Inflammatory factor
