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细胞因子信号转导抑制物与糖尿病的研究进展

Progress in the Relationship of Suppressors of Cytokine Signaling and Diabetes
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摘要 糖尿病的发病机制十分复杂,研究表明糖尿病的发生与胰岛细胞因子信号转导密切相关。最近,细胞因子信号转导抑制物(suppressors of cytokine signaling,SOCSs)对胰岛细胞因子信号转导的调节作用是该领域的一个研究热点,并在1型糖尿病(type 1 diabetes mellitum,T1DM)和2型糖尿病(type 2 diabetes mellitum,T2DM)的病变中具有重要作用。现就SOCSs对糖尿病的作用机制的最新研究进展作一简要的论述。 The pathogenesis of diabetes is extremely complex. Some researches indicated that the occur- rence of diabetes was closely related to the cytokine signaling in the islet cell. Recently, suppressors of cytokine signaling （suppressors of cytokine signaling, SOCSs）, which regulate the cytokine signaling in the islet cell, have been considered to play an important role in the pathological processes related to both type 1 diabetes （type 1 diabetes mellitum, T1DM） and type 2 diabetes （type 2 diabetes mellitum, T2DM）. This article briefly reviews the latest progress related to the role and mechanism of SOCSs in diabetes.
作者 刘芬 万春燕 杨志秋 傅正伟
机构地区 浙江工业大学生物与环境工程学院
出处 《细胞生物学杂志》 CAS CSCD 2009年第1期33-38,共6页 Chinese Journal of Cell Biology
基金 浙江省科技厅重点项目(No.2004C14003)~~
关键词 糖尿病 细胞因子信号转导抑制物 胰岛素抵抗 瘦素抵抗 diabetes mellitum suppressors of cytokine signaling insulin resistance leptin resistance
分类号 R587.1 [医药卫生—内分泌]
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细胞生物学杂志
2009年 第1期

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