摘要
JNK作为进化保守的MAPKs成员之一在生物体内发挥重要的生理功能。大量实验证据表明,JNK介导的信号通路广泛参与调节增殖、凋亡、运动、代谢及DNA损伤修复等细胞生命过程,而JNK信号功能的失调则与多种疾病如缺血/再灌注损伤、神经退行性疾病、糖尿病及癌症等的发生直接相关。近年来,有关该领域的研究已获得了重要突破与进展。现主要介绍JNK信号通路作用于细胞凋亡的分子机制,同时,重点论述JNK介导的细胞凋亡在机体发育中的意义及其失调后所导致的病理变化。
As a member of the conserved mitogen-activated protein kinase family, JNK has important physiological functions. The signaling pathway mediated by the well regulated JNK has been implicated in many cellular processes, such as cell growth, apoptosis, cell motility, metabolism and DNA repair. However, the dysregulated JNK signaling could induce many diseases, like ischemia/reperfusion, neurodegenerative diseases, deafness or cancer. Great progresses and major breakthrough have been made recently in this field. In this review, we will mainly focus on the role of JNK signaling in apoptosis, and the significance of such apoptosis in normal development and patho- genesis of the relevant diseases.
出处
《细胞生物学杂志》
CSCD
2009年第1期21-27,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(No.30470890)
教育部留学回国人员科研启动基金资助项目~~
关键词
JNK
细胞凋亡
死亡受体途径
线粒体途径
发育与疾病
JNK
apoptosis
death receptor pathway
mitochondrial pathway
development and diseases
