摘要
流感嗜血杆菌(Haem ophilus influenzae,Hi)是儿童呼吸道感染的常见致病菌,治疗Hi感染,氨苄西林是历史沿袭的首选药物。近年来,随着抗生素的广泛使用,Hi对氨苄西林的耐药日趋严重,特别是产生β-内酰胺酶(常见的有TEM-1和ROB-1型β-内酰胺酶)。β-内酰胺酶阳性的Hi对多种抗生素耐药。此外,β-内酰胺酶阴性的耐氨苄西林Hi(BLNAR)近年报道增加,而BLNAR的耐药机制更复杂,本文就Hi对氨苄西林的耐药性及其耐药机制作一综述。
Haemophilus influenzae（Hi） is the common pathogenic bacteria of respiratory tract infections in children, and ampicillin is the first-line drug for the bacteria infections treatment. In recent years, with the widespread use of antibiotics, bacteria resistant to ampicillin becomes increasingly serious, especially those which were producing β-lactamase, mainly including TEM-1 and ROB-1 types. β-1actamase positive Hi often resistant to multi- antibiotics. In addition, β-lactamase negative ampicillin-resistant Hi （BLNAR） reported increasingly in recent years, and the mechanism of BLNAR is much more complex. This paper reviewed on the Hi resistance to ampicillin and its resistance mechanism.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2009年第2期69-73,共5页
Chinese Journal of Antibiotics
关键词
流血嗜血杆菌
氨苄西林
耐药
Haemophilus influenza
Ampicillin
Drug resistance
