依那普利对原发性高血压治疗效果和肾功能影响的研究被引量：1

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摘要目的探讨依那普利对原发性高血压(EH)患者的治疗效果和对肾功能的影响,观察其能否降低尿蛋白的排泄从而保护肾功能。方法对我院收治的85例EH在给予2周的冲洗期后进行为期16周的治疗期。治疗期给予依那普利每日晨服1次,剂量为10 mg,其后根据患者情况调整给药剂量。治疗前后测定血清肌酐(Cr)、尿素氮(BUN)、内生肌酐清除率(Ccr)和24 h尿蛋白(UTP)、白蛋白(Alb),尿α1及β2微球蛋白(α1-MG和β2-MG)的排泄率。在治疗第3周、第9周和第16周分别测定患者血压。结果给予依那普利第3周、第9周和第16周分别测定患者血压均有明显降压效果,血压降低有效率分别为44.7%(38/85)、71.8%(61/85)、91.8%(78/85)。给药后患者UTP、Alb,α1-MG和β2-MG的排泄率均有下降(P<0.05)。结论依那普利可降低血压同时还可减轻和延缓高血压引起的肾功能损害,具有较好的临床价值。

作者谭湘恒

机构地区北京丰台铁营医院急诊科

出处《河北医药》 CAS 2009年第1期50-51,共2页 Hebei Medical Journal

关键词依那普利原发性高血压肾功能疗效

分类号 R544.1 [医药卫生—心血管疾病]

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