摘要
目的：研究小鼠被动吸烟对脂质过氧化物（ＬＰＯ）及超氧化物歧化酶（ＳＯＤ）的影响和ＶＣ、ＶＥ联合拮抗作用。方法：各处理组小鼠预先喂不同剂量ＶＣ、ＶＥ后再连续被动吸烟６ｈ／ｄ，３０ｄ后与对照组一同处死，测血清ＳＯＤ活力、肺、脑组织中ＬＰＯ含量。结果：被动吸烟可致小鼠肺脑组织中ＬＰＯ含量增高、ＳＯＤ活性下降。当预先给予ＶＣ可使肺组织中ＬＰＯ含量下降，脑组织中较大剂量（４０ｍｇ·ｋｇ－１·ｄ－１）可发挥作用。预先给予ＶＥ对抑制脑组织中ＬＰＯ生成作用较好。高剂量优于低剂量。ＶＣ、ＶＥ联用，抑制作用明显优于单独作用组。结论：ＶＣ。
Objective:This study is to observe the effects of cigarette smoking on lipid peroxidation(LPO) and superoxide dismutase(SOD) activity in mice and antagonistic effect of VC and VE treatment in combination.Methods:The mice in various groups were fed with different dosages of VC or VE in advance then passively smoked 6 h/d.After 30 days,the mice and the mice in control group were all killed and SOD activity in serum and LPO in lung and brain were determined.Results:Cigarette smoking increased LPO in lungs and brain of mice whereas reduce the SOD activity of serum;in mice fed with VC in advance,the dosage of 20 mg·kg-1·d-1 could reduce LPO in lungs,but the dosage of 40 mg·kg-1·d-1 was needed to reduce LPO in brain.VE fed to mice in advance also exhibited a good prevention of LPO increase in brain,especially with high dosage is better than low dosage.Conclusions:VC and VE in combination exhibit a good prevention in LPO increasing and protection of SOD activity on cigarette smoking mice.
出处
《蚌埠医学院学报》
CAS
1998年第1期4-5,共2页
Journal of Bengbu Medical College
