摘要
术后早期采用小剂量白细胞介素－2（IL－2），2～3周后采用IL－2加卡介苗进行膀胱灌注防治膀胱肿瘤复发，并与单纯灌注卡介苗的患者进行对照，结果表明术后早期膀胱灌注IL－2，患者血中环磷酸腺苷（cAMP）、肿瘤坏死因子（TNF）含量升高；1年及1～4年总复发率降低，效果较单纯灌注卡介苗者优越。提示IL－2膀胱灌注可调节免疫功能，通过cAMP下调癌基因表达及诱导分化，防治肿瘤复发，是防治膀胱肿瘤复发的安全、有效的措施。
In order to investigate the effect and mechanism of low dose interleukin－2(IL－2) intravesical instillation in preventing the recurrence of bladder tumo, 131 patients with bladder tumor were divided into 2 groups. Experimental group were instillated with 2~5 ten thousends IUIL－2 every day from the socond to 7th day after operation. Plasm cAMP and serum TNF were deterndned before and after one week of operation. Then am instillation were carrtal out in controlgroup and BCG plus IL－2 were instillated in experimental group in the same procecure. The resultsshowed that IL－2 instillation enhanced the level of cAMP and TNF,decreaced the recurrence rateof bladder tumor in the first year and 1~4 y6ar after operation. The results indicated that IL－2 instillation might effectively prevent the recurrence of bladder tumor by regulating the inuune function,and inducing differentiation of residul cancer cells through cAMP.
出处
《临床泌尿外科杂志》
1998年第1期18-21,共4页
Journal of Clinical Urology
基金
军队"八五"协作攻关课题
