摘要
脊神经节（ＤＲＧ）损伤常引起感觉及运动功能障碍，为了探索ＤＲＧ不同损伤方式和不同损伤时间的脊髓诱发电位（ＳＥＰ）和ＤＲＧ组织形态学改变，用５２只家兔，分别制成机械压迫、炎性损伤模型，以及２％利多卡因加２．５％醋酸氢化泼尼松局部治疗，并与未损伤组作对比研究。结果表明，ＤＲＧ血管内皮细胞连接间隙增宽是机械性损伤导致血管通透性增加的主要原因，而血管内皮细胞连接间隙增宽，以及血管内皮细胞吞饮小泡转运功能增强，是炎性损伤导致血管通透性增加的主要原因。认为，２％利多卡因加２．５％醋酸氢化泼尼松局部浸润能显著减轻ＤＲＧ炎性损伤。
Injury of dorsal root ganglia (DRG) may cause sensory and motor dysfunction. In order to investigate the changes of somatosensory evoked potential (SEP) and histological characteristics of DRG in different causes and different periods of injury, fiftytwo rabbits were chosed to build the models. The rabbits were divided into 4 groups: Control group (n=4); mechanical compressing group (n=16); inflammatory injury group (n=16); and treatment group (2% lidocaine with hydroprednisone was administered locally, n=16). After one to eight weeks, SEP was determined and samples of DRG were obtained to observe the histological and ultrastructural changes every week. The result showed that the gap junction of microvascular endothelium in DRG had been destroyed by the mechanical compression was the major cause of the vessel permeability increasing. The increasing of endothelial pinocytic vesicles transportation and widening of endothelial gap junction were the main causes of inflammatory irritation of DRG. The local infiltration with 2% lidocaine and hydroprednisone could obviously ameliorate inflammatory injury in DRG.
出处
《中国修复重建外科杂志》
CAS
CSCD
1998年第3期145-149,共5页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
脊神经节损伤
超微结构
组织形态学
电生理
Dorsal root ganglia Somatosensory evoked potential Ultrastructure Lodocaine
