摘要
目的探讨结核蛋白芯片联合PPD皮试检测用于结核性胸膜炎诊断的意义。方法应用结核分枝杆菌蛋白芯片对40例结核性胸膜炎(TP)患者,非结核性胸膜炎(NTP)患者28例患者血清标本进行检测,同时行卡介苗—纯蛋白衍化物(BCG-PPD)皮试。结果TP组结核蛋白芯片阳性率62.50%,NTP组结核蛋白芯片阳性率3.57%,两者比较有显著性差异(P<0.01);TP组PPD强阳性率57.50%,NTP组PPD强阳性率17.86%,有显著性差异(P<0.01);TP患者血清结核蛋白芯片阳性和(或)PPD强阳性共33例,阳性率82.50%,与单独结核蛋白芯片或PPD皮试比较,有显著性差异(P<0.05)。结论结核蛋白芯片联合PPD皮试检测可提高TP诊断敏感性,可作为TP诊断的重要依据。
Objective To evaluate the clinical value of protein-chip combined with PPD on the rapid diagnosis of tuberculous pleutitis. Methods The serum samples of 40 tuberculosis pleuritis patients and 28 non-tuberculosis pleuritis patients were detected anti-TB anti-bodies using protein-chip.And all cases were studied for anti-TB antibodies by PPD method. Results The positive rate of anti-TB anti- bodies were 62.50% in tuberculosis pleuritis. The rate of anti-TB antibodies was 3.57% in the non-tuberculosis pleuritis patients by detection of protein chip（P 〈 0.01 ）. The strong positive rate of anti-TB antibodies were 57.50% in tuberculosis pleuritis. The strong positive rate of anti-TB antibodies was 17.86% in the non-tuberculosis pleuritis patients by detection of PPD （P 〈 0.01 ）. The positive rate of anti-TB antibodies by using protein chip or PPD were 82.50% in tuberculosis pleuritis（P 〈 0.05）. Conclusion The anti-TB antibody protein-chip combined with PPD could enhance sensitity for diagnosis tuberculosis pleuritis, was a kind of important method in diagnosing tuberculosis pleuritis.
出处
《中国现代医生》
2009年第3期17-18,共2页
China Modern Doctor
