摘要
阿苯达唑(Albendazole)为新型广谱驱虫药,应用于治疗囊虫病取得了较好疗效。据报道,阿苯达唑进入人体经肝微粒体单氧加氧酶p-450、NADPH FP_1及FP_2的作用下,转化成阿苯达唑亚砜,为治疗囊虫病的有效成分;继而转化成砜、二氨基砜而失活,据作者实测结果,尿中含有大量阿苯达唑亚砜和砜,尚未转化成最终产物便从尿中排出。而致使血中亚砜浓度迅速下降。通过实测数据,为临床治疗提供参考。
A RP-HPLC mthod was used for assay of sulfoxide and sulfone in human urine after a single oral dose of 25mg albendazole per kilo body weignt. 0.04% metnanol containing acetic acid is employed as mobile phase, and Micro Bondpak [CN 0.39×l5cm l0μ as stationary phase column. U-V detector at 290nm; Mebendazole as internal standard were used. The rates of recovery of the sulfoxide and sulfone in the urine were 98.95 ± 8.9% and 95.81±15.23% respectively. The time of sulfoxide and sulfone peak in the urine of patients occurred 14 hours after taking the albendazole. The means of sulfoxide and sulfone peak values n the urine were 36344.09± 2563.72ng/ml and 3617. 38±570.80/ml, respectively.
出处
《吉林农业大学学报》
CAS
CSCD
1990年第2期92-97,共6页
Journal of Jilin Agricultural University
关键词
阿苯达唑
代谢物
人尿
测定
HPLC, albendazole, sulfoxide, sulfone, the concentration of medicine in the urine.
