摘要
目的探讨系统性红斑狼疮(SLE)患者易合并肺动脉高压的相关临床因素。方法37例SLE合并肺动脉高压的患者作为病例组,78例诊断为SLE而无合并肺动脉高压的患者为对照组。采用病例1对照研究的方法,对各个研究因素采用逐步引入一剔除法,建立Logistic回归模型。结果多因素Logistic回归分析显示,SLE患者易发生肺动脉高压的独立危险因素包括雷诺现象、疾病活动、心悸气促症状、心包积液。结论雷诺现象、疾病活动、心悸气促症状、心包积液是SLE患者易并发肺动脉高压的独立危险因素,对于这4个指标阳性的患者要尽早进行心脏彩色多普勒检查,以进行早期诊断。
Objective To investigate the related clinical factors of pulmonary arterial hypertension （PAH） patients complicated with systemic lupus erythematosus （ SLE ）. Methods Thirty seven cases of patients diagnosed SLE complicated with PAH, and seventy eight cases of patients diagnosed SLE without PAH were enrolled. A case-control study was retrospectively analyzed among two groups. A logistic regression model was established. Results Muhivariates analysis showed that Raynaad＇s phenomenon, SLE activity, palpitations and shortness of breath, pericardial effusion were significantly associated with the happening of PAH in SLE patients. Conclusion Raynaud＇s phenomenon, SLE activity, palpitations and shortness of breath, pericardial effusion are the independent risk factors to SLE patients with PAIl. SLE patients with the above four factors need to undergo Doppler echocardiography examination in order to detect PAH earlier.
出处
《国际内科学杂志》
CAS
2009年第1期9-11,F0003,共4页
International Journal of Internal Medicine
基金
广东省科技计划项目(2007B031500007)
广东省医学科研基金项目(A2006192)
关键词
系统性红斑狼疮
肺动脉高压
病例-对照研究
Systemic lupus erythematosus
Pulmonary arterial hypertension
Case-control study
