摘要
目的探讨不同复苏液体种类对大鼠急性失血性休克微循环的影响。方法对40只纯种Wistar大鼠参照Sandro B．Rizoli所建模型改良复制失血性休克动物模型，根据对急性失血性休克大鼠进行液体复苏时所选液体种类不同，随机分为无液体复苏组（A组）、低分子右旋糖苷-40组（B组）、7．5％高渗盐水组（C组）和高渗盐水＋低分子右旋糖苷-40（D组），每组10只，于休克后24h将动物处死，采集左侧肾皮质相应部位标本用于电镜检查。结果休克无液体复苏组（A组）动物肾脏微循环破坏严重，单独应用低分子右旋糖苷组（B组）或单独应用高渗盐水组（C组）均有不同程度损伤，而联合应用高渗盐水＋低右复苏组（D组）肾脏微循环基本完好。结论不同复苏液体种类对休克机体微循环影响不同，联合应用高渗盐水＋低右对保护肾脏微循环具有良好效果。
Objective To investigate the effects of different means of liquid resuscitation on microeirculation in rats with hemorrhagic shock. Method A model of rats with hemorrhagic shock was established in 40 Wistar rats. The rats were randomly divided into 4 groups according on different means of liquid resuscitation, and killed 24 hours after the examination, group A： without liquid resuscitation; group B： low-molecular-weight-40; group C： 7.5% hypertonic saline, group D： low-molecalar-weight-40 ＋ hyperonic saline. As well as the mierocirculation in kidney was ohserved using electron microscope. Results In group without resuscitation, the microcireulation in kidney damaged severely; While in group with hypertonic or low molecule dextran alone, there was harm with different degrees, and the microcirculation in kidney was nearly perfect in group with both hypertonic and low molecule dextran alone. Conclusions Different means of liquid resuscitation may infect the microcirculation in kidney, which with both hypertonic and low molecule dextran can protect the microcirculation in kidney.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2009年第2期158-160,共3页
Chinese Journal of Emergency Medicine
关键词
休克
失血性
液体复苏
肾皮质
肾脏微循环
Shock
Hemorrhagic
Liquid resuscitation
Renal cortex
Microcirculation kidney
