摘要
目的回顾分析1例淋巴细胞间质性肺炎（LIP）患者的临床资料，探讨LIP的发病机制、诊断和治疗方法。方法回顾分析我院确诊的1例LIP患者的临床特点，并结合文献报道加以总结。结果（1）免疫性疾病、EBV感染可能和LIP发病有关；（2）LIP起病缓慢，主要表现为进行呼吸困难和咳嗽，双肺底听诊可闻及湿啰音，肺功能表现为限制性通气功能障碍伴弥散功能受损；（3）高分辨CT表现为双下肺弥散分布的磨玻璃样改变、模糊的小叶中心结节和胸膜下小结节，小叶间隔增厚、支气管血管束增厚；（4）病理表现为肺间质弥漫性淋巴细胞（以成熟性T细胞为主）浸润；（5）激素对部分患者有效。结论LIP比较少见，确诊有赖于胸腔镜或开胸肺活检，治疗以皮质激素为主。
Objective To explore the pathogenesis, diagnosis and treatment of lymphoid interstitial pneumonia（LIP）. Methods The clinical, radiographical and histopathological characteristics of one case of LIP were analyzed, and the literature was reviewed. Results LIP may be associated with autoimmune diseases, infection of Epstein-Barr virus （EBV）. Clinically, patient is presented with progressive dyspnea and chronic cough. Pulmonary function test showed a restrictive ventilatory defect with a decreased carbon monoxide diffusing capacity. HRCT of chest revealed ground-glass attenuation with centrilobular nodules, subpleural small nodules, bronchovascular bundle thickening and interlobular septal thickening. Main histologic feature of LIP was diffuse interstitial infiltrates of small mature lymphocytes. Some patients have responded to corticosteroids. Conclusion LIP is rare which can be confirmed through thoracoscopic examination or by open lung biopsy specimens. The firste-line of drug treatment of the disease has been corticosteroids
出处
《临床内科杂志》
CAS
2009年第2期101-103,共3页
Journal of Clinical Internal Medicine
关键词
淋巴细胞间质性肺炎
Lymphoid interstitial pneumonia
