摘要
目的:检测非小细胞肺癌(NSCLC)组织中RASSF1A蛋白的表达。方法:采用Western Blot检测96例NSCLC患者癌组织及相应的癌旁正常肺组织中RASSF1A蛋白的表达。结果:①在NSCLC组织中,RASSF1A失表达或低表达率达60.4%(58/96),而相应的癌旁正常肺组织均正常表达,2者比较,差异有统计学意义(P<0.05)。②RASSF1A表达下调或缺失与肿瘤的病理分期和淋巴结转移有关(P<0.05),但与患者的性别、年龄、是否吸烟,肿瘤的组织学类型及分化程度无关(P>0.05)。结论:RASSF1A在中国人NSCLC组织中有较高比例的表达下调或缺失,该蛋白低表达或阴性表达可能促进NSCLC的发生、发展及淋巴结转移。
Aim： To observe the expression of RASSF1A protein in non-small cell lung cancer（NSCLC） tissue. Methods：Western Blot was used to detect the expression of RASSF1A protein in 96 cases of NSCLC tissue and matched normal lung tissue. Results： The RASSF1A protein expression was normal in all normal lung tissue far from cancer area but lower or loss in 60.4% （55/96） carcinoma tissue. The lower or loss expression of RASSF1A protein was related with pathological stage and lymph node metastasis （P 〈 0.05 ）,but not with gender, age, smoking, histological type or differentiation grade of tumors of the patients （all P 〉 0.05）. Conclusion： Lower or loss expression of RASSF1A protein is a frequent event in patients with NSCLS in China, which may play an important role in the malignant progress and lymph node metastasis of NSCLS.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2009年第1期90-92,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金资助项目30571552
