摘要
目的:分析2007年宁波市255例左氧氟沙星不良反应发生的基本情况,为临床药品不良反应监测及合理用药提供参考方法:以Excel电子表格形式下载2007年药品不良反应报告表,对有关数据进行适当转换后,进行统计、分析。结果:255份左氧氟沙星不良反应报告中,累及的系统器官主要为皮肤及其附件(42.55%)、胃肠道系统(11.35%)、神经系统(10.64%)、全身性损害(7.09%)。244例(95.69%)药品不良反应由静脉给药途径所致。新的、严重的不良反应较少(7.05%)。结论:左氧氟沙星不良反应高发生率与临床应用广泛有关,使用管理也亟待加强,包括商品名管理、医生处方规范,特别对老年人要慎重使用,18岁以下未成年人应避免使用,以减少不良反应发生。
Objective： To investigate the essential features of adverse drug reactions （ADR） of levofloxacin in NingBo, and provide information for ADR monitoring and rational drug use. Method ： ADR reports in 2007 were downloaded from the National Center for ADR monitoring by means of Excel. The data of the reports were eollected and analyzed. Result： The lesions of 255 cases of ADR primarily involved skin and its accessories （42.55%）, gastrointestinal system （ 11.35% ） and nerve system（ 10.64% ）, 244（95, 69% ） ADR cases were induced by the intravenous route of administration. New and severe ADR reports were few（ 7.05% ） . Conclusion： Multiple factors led to the high frequency of ADR with complicated reasons. The management of the use of levofloxacin should be strengthened. The management of the commodity name and regularization of presciption should be strengthended to reduce or avoid the occurrence of ADR.
出处
《药物流行病学杂志》
CAS
2009年第1期26-28,共3页
Chinese Journal of Pharmacoepidemiology
