摘要
目的定量分析帕金森病（PD）患者眼球跟踪运动的特点，为评价PD患者的前庭功能提供依据。方法选取30名健康人（对照组）和55例PD患者（PD组）作为受试者，PD组包括静止性震颤起病者31例（静止性震颤组），运动减少起病者23例（运动减少组），混合起病1例。对全部受试者进行眼震电图检查。比较PD组和对照组跟踪运动增益值（gain，G）的差异，运动减少组和静止性震颤组跟踪运动的差异，PD患者双侧跟踪运动的非对称性和健康对照者的差异。结果PD患者双侧跟踪运动的增益值（G左：0．79±0．10、G右：0．78±0．11）较对照组（G左：0．86±0．05、G右：0．85±0．06）明显降低（U=394．500、t=3．547，均P〈0．01），运动减少组（G左：0．79±0．14、G右：0．75±0．14）与静止性震颤组（G左：0．79±0．06、G右：0．81±0．07）眼球跟踪运动增益值差异无统计学意义（t=-0．100、2．005，均P〉0．05）。病例组左右两侧的跟踪运动非对称性（1．03±0．97）明显大于对照组（0．87±0．86，U=755．500，P〈0．05）。结论PD患者眼球跟踪运动速度明显减慢，但不存在类型间的差异，两侧跟踪运动存在不对称性。
Objective To evaluate the eyeball movement examination on Parkinson＇ s disease （PD） and investigate their vestibular function. Methods Thirty healthy volunteers and 55 PD patients served as subjects. Thirty-one patients had bradykinesia, 23 patients had resting tremor at first visit and 1 had both. Electronystagmogram examinations were performed in all the subjects. The eyeball movment gain （G） of PD group was compared with controls and the difference between the bradykinesia group and resting tremor group was analyzed. Dissymmetry of the bilateral pursuit movement was investigated. Results The eyeball movement gains decreased in PD patients （ Left G 0.79 ±0. 10,Right G 0. 78 ±0. 11 ） significantly （ U = 394. 500,t = 3. 547, P 〈 0. 01 ） compared with controls （ Left G 0. 86 ±0. 05, Right G 0. 85 ± 0.06）. There was no difference （t = -0. 100,2. 005, P 〉 0. 05 ） between the bradykinesia group （Left G 0. 79 ± 0. 14,Right G 0. 74 ±0. 14） and the resting tremor group （ Left G 0. 79 ±0. 06,Right G 0. 81 ±0. 07）. The dissymmetry of the bilateral movement increased significantly （ U = 755. 500, P 〈 0. 05 ） in PD group （1.03 ± 0. 97） than in controls （0. 87 ± 0. 86）. Conclusion The velocity of the eyeball movement has decreased in patients with PD. There is no difference of the pursuit gain between bradykinesia group and the resting tremor group. The bilateral vestibular function is involved dissymmetrically.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2009年第1期46-49,共4页
Chinese Journal of Neurology
关键词
眼球运动
帕金森病
眼震电图描记术
Eye movements
Parkinson disease
Electronystagmography
