摘要
目的：测血药浓度，３Ｐ８７药动学程序进行药物动力学参数模拟，双单侧检验法作生物等效性判别。方法：８名健康男性志愿者交叉服用萘普生肠溶和胃溶胶囊各５００ｍｇ，以ＨＰＬＣ法测定。结果：药－时曲线符合一级吸收二室模型，萘普生肠溶胶囊的主要药动学参数分别为Ｋａ０．７５±０．２８ｈ－１，ＡＵＣ１５３３．０±２１７．６μｇ·ｈ·ｍｌ－１，Ｔｍａｘ３．６±１．６ｈ，Ｃｍａｘ７８．１±１４．１μｇ·ｍｌ－１。结论：胃溶胶囊的药动学参数与肠溶胶囊的药动学参数相似，肠溶胶囊的相对生物利用度为１０４．０１％。
harmacokinetics and relative bioavailability of enteric naproxen capsules were studied in 8 healthy subjects after oral single dose administration of 500 mg,serum naproxen concentration was determined by HPLC.The results showed that the serum concentrationtime profile was fitted to onedepartment model with first order absorption and elimination,the parameters of enteric capsules were Ka 0.75±0.28h -1 ,AUC1533.9±218.1 μg\5h\5ml-1,Tmax3.6±1.6h,Cmax78±14 μg\5ml-1,no significant difference in two preparations(P>0.05).The relative bioavailability was 104.01 %.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1998年第5期195-197,共3页
Chinese Journal of Hospital Pharmacy
