摘要
应用比色法测定了３４例胃癌患者血清和组织粘膜的一氧化氮（ＮＯ）含量，并设３０例正常人及３０例球部溃疡为血清对照组。２３例组织对照组系取自癌旁组织（肉眼和病理均属正常）。结果显示胃癌患者血清一氧化氮水平明显低于正常对照组及十二指肠球溃疡组（Ｐ＜０．０１）；而十二指肠球溃疡组则明显高于正常对组（Ｐ＜０．０１），胃癌组织中ＮＯ含量则显著高于癌旁组织（Ｐ＜０．０１）。研究表明当肿瘤发生时，经诱导活化的巨噬细胞可以产生大量的ＮＯ於病灶组织中而发挥其免疫功能，即ＮＯ直接作用于肿瘤细胞，启动机体其他免疫防御系统而杀伤肿瘤细胞并在粘膜损伤时有重要的修复功能。故而表现出血中ＮＯ水平下降，而胃癌组织局部ＮＯ水平升高。
The levels of nitric oxide (NO) were determined in the serum and tumor tissue from 34 gastric cancer (GC) patients using colorimetry. Serum samples from 30 normal individuals and 30 patients with duodenal ulcer (DU),and 23 paracancerous tissues (PCT) were taken as control. The results revealed that the serum NO levels in GC patients were lower than those in normal individuals and DU patients (P<0.01). Serum NO levels were higher in DU patients than those in the normal controls (P<0.01). Levels of NO in GC tissues,however,were higher than those in PCT group (P<0.01). This study suggests that NO produced by activated macrophagocytes in the tumor tissue plays the part of immunomodulation.It is postulated that NO acts on tumor cells directly and kills the tumor cells by regulating immunosystemic functions in the repairment of damaged mucosa.This explains that NO level decreases in serum, but increases in tissue of gastric cancer. It is inferred that determination of NO in the serum might be helpfulin distinguishing benign from malignant disease of the stomach. In light of the dual action of NO,it is suggested that promotion or inhibition of NO synthesis either of them might be beneficial in the treatment of gastric cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第4期285-286,共2页
Chinese Journal of Clinical Oncology
基金
江苏省扬州市科委科技发展基金
