摘要
采用酶联免疫吸附法（ＥＬＩＳＡ）对６２例肺癌患者及６１例健康人进行了血清ＳＴＮＦＲＩ的测定。结果显示肺癌组ＳＴＮＦＲＩ值显著高于健康对照组（分别为２．８４±１．１８ｎｇ／ｍｌ、０．９３±０．２９ｎｇ／ｍｌ，两组比较Ｐ＜０．０１）且ＳＴＮＦＲＩ水平随肺癌病期进展而升高，Ⅰ、Ⅱ、Ⅲ、Ⅳ期分别为２．２３±０．４７ｎｇ／ｍｌ、２．３４±０．６８ｎｇ／ｍｌ、２．６３±０．６７ｎｇ／ｍｌ、３．５１±１．６２ｎｇ／ｍｌ。在本组测定中发现肺癌患者ＳＴＮＦＲＩ阳性率（８０．７％）显著超过了常用的肺癌肿瘤标志物——血清癌胚抗原（ＣＥＡ）的阳性率（３８．７％）。本文研究表明测定血清中ＳＴＮＦＲＩ对肺癌的诊断。
The serum soluble tumor necrosis factor receptor (STNFR) level was measured with ELISA assay in 62 patients with lung cancer,and 61 healthy adults as control.The level of STNFR was significantly increased in lung cancer than that in the controls (2.84±1.18ng/ml versus 0.93±0.29ng/ml,P<0.01) and increased with the escalation of clinical stages(2.23±0.47ng/ml, 2.34±0.68ng/ml, 2.63± 0.67ng/ml, 3.51±1.62ng/ml for stage I,II,III,IV respectively). In patients with lung cancer the positive rate of serum TNFR level was 80.7% which greatly exceeded that of the conventional lung cancer markerCEA(38.7%).It is concluded that determination of serum TFNR is useful in diagnosis,classification and prediction of prognosis of lung cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第4期263-265,共3页
Chinese Journal of Clinical Oncology
关键词
肿瘤坏死因子
受体
肺癌
诊断
Serum Receptor Tumor necrosis factor Lung cancer
