摘要
以生物定量法测定３５例肝硬化患者及正常对照１０例血中的血小板激活因子（ＰＡＦ）水平。结果：肝硬化患者血中ＰＡＦ含量为２２７．７４±２７．６０ｎｇ／ｍｌ，显著高于对照组的１０６．４４±１４．３６ｎｇ／ｍｌ，Ｐ＜０．０１。肝硬化Ｃｈｉｌｄ－ｐｕｇｈ分级中的Ｂ和Ｃ级患者ＰＡＦ含量分别为２３１．９３±１９．３７及２３２．７４±２８．６７，二者明显高于Ａ级患者的１８３．４４±１９．０９，Ｐ＜０．０５。结论提示肝硬化患者在内毒素的诱导下通过单核巨噬细胞系统合成ＰＡＦ增加。文中对ＰＡＦ在肝损伤。
The blood PAF of 35 patients with liver cirrhosis and 10 normal controls were measured by using the rabbit platelet aggregation method.The results showed the levels of PAF were significantly higher in cirrhosis with the patients(22774±2760 ng/ml)than that of the normal controls(10644±1436),P<0001.According to the classification of ChildPugh in cirrhosis,the blood levels of PAF in B and C class were significantly higher(23193±197 and 23276±286ng/ml)than those and in the class A patient(18344±1909ng/ml).Our results suggest that PAF is one of the cytokines which plays an important role in the pathophysiological process of the liver damage,fibrosis and cirrhosis.
出处
《临床肝胆病杂志》
CAS
北大核心
1998年第2期99-101,共3页
Journal of Clinical Hepatology
关键词
血小板激活因子
血液
肝硬变
liver cirrhosis plateletactivating factor
