摘要
通过4-[(2-氰基亚胺基-1,3-噻唑烷-3-基)甲基]-2-氨基噻唑与取代苯甲醛的缩合反应,合成了14个新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物5.所有化合物的结构均经1HNMR和元素分析确证,并通过X射线单晶衍射分析测定了化合物5a的晶体结构.初步生物活性试验结果表明,部分目标化合物具有一定的杀菌活性和植物生长调节活性.
Fourteen new imine derivatives 5 containing 2-substituted-1,3-thiazolidine and thiazole rings were synthesized by the condensation of 2-cyanoimino-3-（2-aminothiazol-4-ylmethyl）thiazolidine with various substituted benzaldehydes. The structures of the title compounds were characterized by ^1H NMR spectra and elemental analysis. The structure of 5a was also determined by X-ray diffraction analysis. Preliminary bioassay showed that some of the target compounds exhibited fungicidal and plant growth regulatory activities to some extent.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第1期123-127,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20772068)
国家科技支撑计划重点(No.2006BAE01A01-5)资助项目
关键词
2-取代-1
3-噻唑烷
噻唑
亚胺
合成
生物活性
2-substituted-1,3-thiazolidine
thiazole
imine
synthesis
biological activity
