摘要
以芳甲酰肼和对硝基苯甲酰氯为主要原料,合成出了10个酰氨基硫脲化合物5a～5j,其中有6个(5d,5f～5j)为新化合物.在无需任何酸性催化剂条件下,将制得的酰氨基硫脲在DMF中加热回流直接脱水关环合成出了9个2-芳基-5-(4-硝基苯甲酰氨基)-1,3,4-噻二唑化合物6a～6i,其中7个(6b～6d,6f～6i)为新化合物.利用IR和1HNMR证明了化合物5存在两种异构体.目标产物的结构通过IR,1HNMR和元素分析进行了表征.
Ten 1-（4-nitrobenzoyl）-4-[（un）substituted benzoyl]thiosemicarbazides 5a-5j were obtained by the reaction of （un）substituted-benzohydrazides with 4-nitrobenzoyl chloride under microwave irradiation and phase transfer catalysis. And then, nine 2-[（un）substituted phenyl]-5-（4-nitrobenzamido）-1,3,4-thiadia- zoles 6a-6i were synthesized by the compounds 5 under reflux in DMF. The compounds 5d, 5f-5j, 6b- 6d and 6f-6i are new compounds. The two isomers of compounds 5 were demonstrated by IR and ^1H NMR. The structures of the target compounds 6 were characterized by IR, ^1H NMR spectra and elemental analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第1期82-88,共7页
Chinese Journal of Organic Chemistry
基金
辽宁省教育厅高等学校科研(No.2008345)资助项目
关键词
1
3
4-噻二唑
合成
表征
1,3,4-thiadiazole
synthesis
characterization
