摘要
为了优化脂肪族聚酯和聚磷酸酯在药物控释及基因治疗领域的性能,以己二酰氯、二氯磷酸乙酯和二缩三乙二醇为原料,用共缩聚的方法合成了一类新型脂肪族酯和磷酸酯的共聚物.运用1HNMR,IR对共聚物的结构进行了表征;利用MALDI-TOFMS测定了共聚物的分子量;研究了反应时间、投料顺序、溶剂、反应温度和缚酸剂对聚合反应的影响;通过动态接触角的测定,探讨了此类聚合物的亲疏水性能;以中性红为模型药物,研究了该类聚合物的药物缓释性能.
To optimize the biomedical application of aliphatic polyester and polyphosphoester, a series of copolymers containing aliphatic polyester and polyphosphoester segments in the repeat units were synthesized via condensation polymerization reaction with adipoyl chloride, ethyl dicholorophosphate and triethylene glycol as the beginning materials. The effects of reaction conditions on polymerization were studied and the structures of final polymers were characterized by ^1H NMR, FT-IR and MALDI-TOF MS. Dynamic contact angle was used to characterize the surface capability of the polymers. The controlled release character of the copolymers was studied by a fluorescence method using neutral red as a model drug.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第1期66-70,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20774073)
陕西省教育厅专项科研计划(No.07JK416)资助项目
关键词
脂肪族聚酯
聚磷酸酯
动态接触角
中性红
药物缓释
aliphatic polyester
polyphosphoester
dynamic contact angle
neutral red
drug release
