摘要
目的探讨各种危险因素在脑卒中患者中的构成比,并对脑梗死与脑出血的危险因素进行比较,为脑卒中防治提供依据。方法收集1995—2002年福建医科大学附属第一医院急性脑卒中住院病例1875例,其中缺血性脑卒中1504例,出血性脑卒中371例;男1216例,女659例;平均年龄(73.42±10.35)岁,对两种脑卒中类型的多种危险因素进行描述性对比分析研究。结果高血压、脉压增大是本组脑卒中患者突出的危险因素。相对于脑出血,与脑梗死相关更密切的危险因素依次是房颤(OR=3.942)、糖尿病(OR=3.674)、肥胖(OR=3.647)、高纤维蛋白原(OR=2.781)、高血压家族史(OR=2.573)、高LDL-C(OR=2.167)、高甘油三酯(OR=1.976)、吸烟(OR=1.849)、年龄增大(OR=1.588)、低Apo A(OR=1.460)(P<0.05)。相对脑梗死,仅高血压(OR=0.545)和饮酒(OR=0.662)与脑出血有更显著的相关性(P<0.05)。除共同危险因素外,高尿酸血症和低HDL-C血症与男性脑梗死关系更密切,而肥胖、高LDL-C及高纤维蛋白原血症与女性脑梗死相关性更强。结论高血压、饮酒是脑出血患者主要的危险因素。相对于脑出血,与脑梗死相关密切的危险因素除了高血压外,依次为房颤、糖尿病、肥胖、高纤维蛋白原、高血压家族史、高LDL-C等。不同危险因素对男女脑梗死的影响不同。
Objective To investigate the constituent ratio of various risk factors for stroke and to identify risk factors for acute cerebral infarction （CI） versus intracerebral hemorrhage （ICH）. Methods Risk factors for stroke subtype in 1875 patients,consisting of 1504 patients with acute CI and 371 patients with ICH ,were analyzed. Results Hypertension and higher pulse pressure were the most prominent factors for overall stroke. The factors were significantly associated with CI as opposed to ICH were atrial fibrillation（OR =3. 942） , followed by diabetes mellitus（OR=3. 674）, obesity（OR =3. 647）, hyperfibrinogenemia （OR = 2. 781）, family history of hypertension（OR = 2. 573）, promoted serum low-density lipoprotein cholesterol （LDL-C） （OR = 2. 167）, hypertriglyceridemia（OR= 1. 976）, smoking（OR = 1. 849）, increasing age （OR = 1. 588） and low serum apolipoprotein A（Apo A） （OR= 1. 460,P〈0. 05）. Hypertension （OR ：0. 545） and drinking（OR =0. 662） were the significant factors associated with ICH versus CI（P〈0.05）. Hyperuricacidemia and lower HDL-C were the significant factors for males with CI. Obesity and Hypercholesteremia were the significant factors for females with CI. Conclusion Hypertension and drinking are the most important risk factors for ICH. Hypertension,atrial fibrillation, diabetes mellitus,obesity, hyperfibrinogenemia , family history of hypertension and promoted serum LDL-C should be the most powerful factors associated with CI rather than ICH. Different effects of risk factors on stroke are found in male and femal patients.
出处
《中国实用神经疾病杂志》
2009年第1期47-51,共5页
Chinese Journal of Practical Nervous Diseases
关键词
脑出血
脑梗死
危险因素
Intracerebral hemorrhage
Cerebral infarction
Risk factors
